'Radiogenetics' Seeks to Remotely Control Cells & Genes
SOURCE: Rockefeller University
It’s the most basic of ways to find out what something does, whether it’s an unmarked circuit breaker or an unidentified gene — flip its switch and see what happens.
New remote-control technology may offer biologists a powerful way to do this with cells and genes. A team of researchers is now developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs.
Published in the journal Nature Medicine, the team describes successfully using electromagnetic waves to turn on insulin production to lower blood sugar in diabetic mice. Their system couples a natural iron storage particle, ferritin, to activate an ion channel called TRPV1 such that when the metal particle is exposed to a radio wave or magnetic field it opens the channel, leading to the activation of an insulin producing gene. Together, the two proteins act as a nano-machine that can be used to trigger gene expression in cells.
"The method allows one to wirelessly control the expression of genes in a living animal and could potentially be used for conditions like hemophilia to control the production of a missing protein. Two key attributes are that the system is genetically encoded and can activate cells remotely and quickly," says Jeffrey Friedman, Marilyn M. Simpson Professor head of the Laboratory of Molecular Genetics at Rockefeller. "We are now exploring whether the method can also be used to control neural activity as a means for noninvasively modulating the activity of neural circuits." Friedman and his Rensselaer colleague Jonathan S. Dordick were co-senior researchers on the project.
Researchers Develop "Radio-genetics" – New Method Triggers Gene Expression With Radio Waves or Magnetic Field (https://news.rpi.edu/content/2014/12/15/radio-genetics-triggers-gene-expression-magnetic-field)
The new system, dubbed radiogenetics, uses a signal, in this case low-frequency radio waves or a magnetic field, to heat or move ferritin particles. They, in turn, prompt the opening of TRPV1, which is situated in the membrane surrounding the cell. Calcium ions then travel through the channel, switching on a synthetic piece of DNA the scientists developed to turn on the production of a downstream gene, which in this study was the insulin gene.
"The use of a radiofrequency-driven magnetic field is a big advance in remote gene expression because it is non-invasive and easily adaptable," says Dordick, who is Howard P. Isermann Professor of Chemical and Biological Engineering and vice president of research at Rensselaer. "You don't have to insert anything -- no wires, no light systems -- the genes are introduced through gene therapy. You could have a wearable device that provides a magnetic field to certain parts of the body and it might be used therapeutically for many diseases, including neurodegenerative diseases. It's limitless at this point."
The team's positive results suggest other applications for the system. In late September, Stanley received a first-round BRAIN grant from the ambitious federal initiative seeking to create a dynamic map of the brain in action. Stanley and colleagues plan to adapt this system to switch neurons on and off, and so examine their roles within the brain.
"In this current study, we've shown that by opening the TRPV1 channel to allow calcium ions to enter the cell, we can turn on a gene. Since neurons can be depolarized by calcium and other positively charged ions, such as those the TRPV1 channel controls, we hope that this system may be effective at regulating neural activity."
Ferritin Stores & Releases Iron (http://www.chemistry.wustl.edu/~edudev/LabTutorials/Ferritin/Ferritin.html) in the body when its needed through channels. This is an example of a "Controlled Delivery System (http://www.chemistry.wustl.edu/~edudev/LabTutorials/Ferritin/Ferritin.html)"
Ferritin is the Protein within the body that Stores Iron and Releases It Through Channels in a Controlled Fashion. (http://www.chemistry.wustl.edu/~edudev/LabTutorials/Ferritin/Ferritin.html)
So now that we know that Ferritin is a natural DRUG DELIVERY SYSTEM then Can We Safely Assume They Will Use Ferritin in the COVID Vaccines?
Ferritin Nanoparticles (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831262/) WILL be used in the COVID Vaccines.
Ferritin Nanoparticle (NP)-based SARS-CoV-2 Receptor-Binding Domain (RBD) Vaccine (https://www.nature.com/articles/s41423-021-00643-6)
In other words they will use a Ferritin Nanoparticle (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831262/) to "ACT AS THAT EXACT PROTEIN" EXCEPT instead of Releasing Iron it will be Releasing Biological Agents.
NANOTECHNOLOGY IN CHEMICAL WARFARE
Remember that Nanoparticles Combined with Chemicals can be EASILY used to Make BIOWEAPONS!
Nanotechnology-Based Chemical Weapons
It has been noted that many aspects of Nanotechnology lend themselves to creating more Powerful Chemical Weapons (https://www.azonano.com/article.aspx?ArticleID=3205).
The Main Use of Current Nanotechnology in Chemical Weapons would be derived from the Research into "Nano-Enhanced" "Drug Delivery Systems" by "Nanoformulating Chemical Agents" to be absorbed by the body more readily.
In order to prove these COVID Vaccines are Actually Biological Weapons Cleverly DISGUISED as a life saving TREATMENT, we need to ask ourselves the following questions.
Are the COVID Vaccines using Nano-Enhanced Drug Delivery Systems?
Nanotechnology and Nanomaterials Solutions for COVID-19: "Drug Delivery & Therapeutics" (https://www.globenewswire.com/news-release/2020/05/07/2029587/0/en/Nanotechnology-and-Nanomaterials-Solutions-for-COVID-19-Diagnostic-Testing-Antiviral-and-Antimicrobial-Coatings-and-Surfaces-Air-Borne-Filtration-Facemasks-PPE-Drug-Delivery-and-Th.html)
Are these COVID Vaccines using Nanoformulating Chemical Agents?
Engineers Design PROGRAMMABLE RNA Vaccines (https://news.mit.edu/2016/programmable-rna-vaccines-0704)
The vaccine consists of strands of genetic material known as Messenger RNA (MRNA), which can be DESIGNED TO CODE for ANY VIRAL, BACTERIAL, or PARASITIC PROTEIN.
This Nanoformulation Approach allows us to make vaccines against new diseases in only seven days.
BLOOD BRAIN BARRIER
Blood-Brain Barrier Dysfunction in Hemorrhagic Transformation: a Therapeutic Opportunity for Nanoparticles and Melatonin https://journals.physiology.org/doi/abs/10.1152/jn.00638.2020
Will this be used in the COVID Vaccines?